FORMULATION AND EVALUATION OF CLOBETASOL-17-PROPIONATE-LOADED CARBOXYMETHYL CHITOSAN NANOPARTICLE

Objective: Formulation and evaluation of clobetasol-17-propionate-loaded carboxymethyl chitosan nanoparticle. Psoriasis is a chronic skin disorder caused due to the autoimmune factors. It has detrimental psychological physiological impact on patients emergence apparent skin. The systemic therapy with anti-psoriatic drugs such corticosteroids, immunosuppressant, gene suppressors causes severe side effects. As result, increasing effectiveness safety aforementioned medicines when applied topically would be extremely useful in avoiding effects associated route administration. Methods: Chitosan (CS) not been widely used clinic applications but its limited solubility poor mechanical characteristics. CS, other hand, chemically changed form (CMC), which soluble at both neutral basic pH. Chemical modifications can also attach different functional groups control hydrophobic, cationic, anionic properties. CMC promising carrier that might possibly traverse thick scales psoriatic since it penetration enhancer allows drug diffusion through either transcellular or paracellular pathways. Comparative study done using as polymer CD polymer. Results: CP-loaded nanoparticles show better result results than Conclusion: Clobetasol-17-propionate-loaded nanoparticle shows improved solubility.